Construction Track: Computational Biology

Course Catalog & Credential Pathway — Dwg. No. PF-002A

Computational Biology

Ed. 2026–27grades 9–12 + post-secondary

A field branch of the Construction Track, for students aimed specifically at AI-for-science and drug-discovery research roles — the same architectures, pointed at protein structure instead of language.

Field branch of Dwg. No. PF-002, The Construction Track — same core sequence through Phase II, concentrated here into computational biology & AI drug discovery from Phase II onward. See also Dwg. No. PF-001, The Verification Track.

Working premise: the bottleneck in AI development isn't access to a model — it's mathematical maturity, systems fluency, and the ability to read a paper on Monday and have a working reimplementation by Friday. In computational biology that bottleneck has a second half: a model can propose a protein structure or a candidate molecule in seconds, but only a graduate who knows biochemistry can tell whether the proposal is real. AlphaFold and RFdiffusion didn't remove that judgment from the pipeline — they moved it downstream, to whoever reads the output.

Five core strands, plus the domain strand this branch concentrates in

MATH
Mathematical Foundations
Linear algebra, calculus, probability, optimization — the language every architecture is written in.
ENG
Software & Systems Engineering
Data structures, distributed computing, performance at scale.
ML
Machine Learning & Deep Learning
Architectures, training dynamics, why a model behaves the way it does.
RES
Research Practice
Reading a paper closely enough to rebuild what's inside it.
BLD
Build & Ship
Open-source contribution, deployment, production ML that survives contact with real load.
BIO
Biochemistry & Structural Biology
This branch's concentration — the domain layer that lets a graduate judge a model's output, not just generate it.
Phase I

Foundations

Grades 9–10

No frameworks yet, and no biology yet either. Two years of straight math and programming fundamentals, identical to the core Construction Track — the deficit that shows up latest and hurts most in this field is always a weak math foundation, not an unfamiliar wet-lab term.

CodeDescriptionStrandLoad
MATH 101

Precalculus, Accelerated

Compressed to clear room for calculus by grade 11 — the standard on-ramp for anyone headed toward a quantitative degree.

MATH
1.0 credit
CS 100

Programming I — Python

Variables, control flow, functions, data structures. Fluency, not tricks.

ENG
1.0 credit
MATH 110

Discrete Mathematics & Logic

Sets, proofs, graphs, combinatorics — the math CS theory actually runs on, usually skipped until it's overdue.

MATH
0.5 credit
ENG 105

Technical Writing for Research

Writing a clear methods section and an honest results section — the two paragraphs every paper lives or dies on.

RES
0.5 credit
Phase II

Applied Practice

Grades 11–12

The math and CS sequences converge into an actual first model, same as the core track. The domain layer begins here too, concurrently — by the end of Phase II a student can both train a small model and read a protein structure paper without translation help.

CodeDescriptionStrandLoad
MATH 201

Calculus I & II

Through multivariable and the gradient — backpropagation is the chain rule with bookkeeping, and it should read that way.

MATH 101

MATH
1.5 credit
MATH 210

Linear Algebra

Vector spaces, eigendecomposition, matrix calculus. Every tensor operation is this course wearing a framework's syntax.

MATH 101

MATH
1.0 credit
STAT 220

Probability & Statistics for ML

Distributions, estimation, Bayes — framed toward loss functions and uncertainty, not toward the social-science stats track.

MATH
1.0 credit
CS 210

Data Structures & Algorithms

Complexity analysis and the standard structures, drilled to fluency — still the baseline technical-interview bar at every AI lab.

CS 100

ENG
1.0 credit
ML 230

Intro to Machine Learning

Regression through a first neural net, built from array operations before any framework is allowed to hide the mechanics.

MATH 210, STAT 220

ML
1.0 credit
RES 240

Research Seminar — Reading Group

Weekly seminal-paper reads (perceptron through transformers), presented and defended aloud, not just summarized.

RES
0.5 credit
CHEM 215

Organic Chemistry & Biochemistry Foundations

Molecular structure, reaction mechanisms, protein and nucleic-acid chemistry — the vocabulary every course below this one assumes.

MATH 201 (concurrent)

BIO
1.0 credit
BIO 225

Structural & Molecular Biology

Protein folding, binding, enzyme kinetics — what a docking score or a binding-affinity number actually means, and why a chemically valid molecule can still be biologically useless.

CHEM 215

BIO
1.0 credit
Phase III

Apprenticeship

Post-HS, Yrs 1–4

Here the domain degree takes over from the general CS/applied-math track. A joint computational biology, bioinformatics, or chemistry-plus-CS program replaces DEG 300 — the credential and peer network it buys are specific to this field, not interchangeable with a general CS degree.

CodeDescriptionStrandLoad
DEG 300

Computational Biology / Bioinformatics Degree

Formal core in a joint comp-bio, bioinformatics, or chemistry-plus-CS program — the credential and the peer network both matter here, and both are field-specific.

BIO
variable
BIO 330

Computational Biology & Structure Prediction

Sequence-to-structure methods from Rosetta through AlphaFold and RFdiffusion, cheminformatics representations, and molecular-dynamics basics — the applied layer between ML 310's architectures and a result a wet lab would trust.

BIO 225, ML 230

BIO
1.5 credit
ML 310

Deep Learning for Structural Biology

Transformer and diffusion architectures in depth, taught directly against the systems that made them famous in this field — AlphaFold's structure module, RFdiffusion's generative backbone design — rather than as a generic survey.

ML 230

ML
2.0 credit
ENG 320

Systems for ML

Distributed training, GPU/accelerator programming, the infrastructure that turns a notebook model into one that trains at scale — the same infrastructure a structure-prediction pipeline runs on.

CS 210

ENG
1.5 credit
RES 350

Supervised Research Practicum

Placement inside a computational-biology or drug-discovery lab, with a mentor of record. Graded on a reproduction that actually reproduces, or a contribution that gets merged.

RES 240, ML 310

RES / BLD
2 semesters
BLD 360

Capstone — Build & Ship

One model or tool — a docking pipeline, a structure-prediction fine-tune, a molecule-screening service — taken from idea to a deployed, load-bearing artifact with real users.

ENG 320, RES 350

BLD
1.0 credit
Note: RES 350 and BLD 360 keep the same credit weight and sequencing as the core Construction Track — only the placement changes, into a computational-biology or drug-discovery group specifically.
Phase IV

Continuing Education

No end date, for two compounding reasons: the field's ML baseline moves every conference cycle, and the wet-lab validation baseline moves on its own, slower schedule that a purely computational graduate can lose track of.

Read weekly Reproduce monthly Ship ongoing Publish on result
Weekly
Paper tracking Follow arXiv's q-bio feed and the major lab blogs — DeepMind, Baker Lab, Isomorphic — not everything, one narrow feed read closely.
Monthly
Reproduction sprint Reimplement one result from a tracked paper — a structure prediction, a binding-affinity model. The one that won't reproduce is usually more instructive.
Ongoing
Ship something load-bearing Keep at least one deployed artifact — a screening tool, a structure-visualization service — with real users.
On result
Publish or contribute A workshop paper, a blog writeup, or a merged PR against an open-source structure-prediction or docking tool.
Drawing
PF‑002A
Pair
PF‑002 Construction
Edition
2026–27
Strands
MATH ENG ML RES BLD BIO